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Resistance to clindamycin is most often caused by modification of specific bases of the 23S ribosomal RNA. Cross-resistance between clindamycin and lincomycin is complete. Because the binding sites for these antibacterial drugs overlap.cross-resistance is sometimes observed among lincosamides.macrolides and streptogramin B. Macrolide-inducible resistance to clindamycin occurs in some isolates of macrolide-resistant bacteria. Macrolide-resistant isolates of staphylococci and beta-hemolytic streptococci should be screened for induction of clindamycin resistance using the D-zone test.

Use with caution in patients with history of gastrointestinal disease.especially colitis.

Use caution in hepatic impairment.monitor for hepatic abnormalities. periodic liver enzyme determinations should be made when treating patients with severe liver disease.

Vaginal yeast infections in women are caused by an organism called Candida albicans . Symptoms of a vaginal yeast infection include vaginal pain with urination.vaginal discharge.odor.and itching.

any change in bowel habits. severe stomach pain.diarrhea that is watery or.

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